High Serum Ratio of Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) to Placental Growth Factor (PIGF) and High Level of Low-Density Lipoprotein (LDL) as Risk Factors of Preeclampsia

Preeclampsia is an obstetric disease that a health problem worldwide, including in Indonesia. Several studies have shown changes the maternal spiral arteries are thought to lead preeclampsia. this decade has been associated with angiogenesis regulatory proteins originating from placenta and circulating mother's blood circulation, namely soluble FMS-like tyrosine kinase 1 (sFlt-1) placental growth factor (PlGF). The author was interested examining ratio of sFlt-1/PIGF low-density lipoprotein (LDL) incidence preeclampsia pregnant women. This study used case control analytic observational design. research sample selected by consecutive sampling 20 cases controls. Univariate analysis describe patient characteristics descriptively, bivariate determine relationship between 2 variables There no significant difference subjects. Low PIGF levels risk for (OR 4.33; p 0.0302) cut-off value 24.5. High sFlt-1 0.027) 869.5. A high 4.33 0.030) 38. LDL 6.0; 0.013) 150 ,2. (PIGF), (sFlt-1), factors